It is a structural analog of AM-2201 in which the central indole ring has been replaced by indazole.

We are suppliers of THJ-2201 (1-?[(5-?fluoropentyl)-?1H-?indazol-?3-?yl](naphthalen-?1-?yl)methanone) is a synthetic cannabinoid and analog of AM-2201. It has been marketed by many research chemical vendors as a legal alternative to the popular AM-2201, which had been banned in 2011.

Cannabinoids for sale are commonly smoked or vaporized to achieve a quick onset of effects and rapid offset. THJ-2201 is orally active when dissolved in a lipid, which can increase the duration significantly. Like other cannabinoids, it is insoluble in water but dissolves in ethanol and lipids.

Unlike cannabis, the chronic abuse of synthetic cannabinoids has been associated with multiple deaths and more dangerous side effects and toxicity in general. Therefore, it is strongly discouraged to take this substance for extended periods of time or in excessive doses.

What is THJ-2201 ?

THJ-2201 (1-​[(5-​fluoropentyl)-​1H-​indazol-​3-​yl](naphthalen-​1-​yl)methanone) is a synthetic cannabinoid and analog of AM-2201. It has been marketed by many research chemical vendors as a legal alternative to the popular AM-2201, which had been banned in 2011.

Cannabinoids are commonly smoked or vaporized to achieve a quick onset of effects and rapid offset. THJ-2201 is orally active when dissolved in a lipid, which can increase the duration significantly. Like other cannabinoids, it is insoluble in water but dissolves in ethanol and lipids.

Unlike cannabis, the chronic abuse of synthetic cannabinoids has been associated with multiple deaths and more dangerous side effects and toxicity in general. Therefore, it is strongly discouraged to take this substance for extended periods of time or in excessive doses.

Chemistry of THJ-2201

THJ-2201, or 1-​[(5-​fluoropentyl)-​1H-​indazol-​3-​yl](naphthalen-​1-​yl)methanone, is a synthetic cannabinoid drug containing a substituted indazole group. This indazole moeity is substituted at R1 with a fluoropentyl chain, a substitution shared with 5F-PB-22 and 5F-AKB48. Additionally, the indazole core is substituted at R3 with a carbonyl group which is also bonded to a napthalene moeity. Napthalene is a bicyclic structure of two fused benzene rings, and is also found in THJ-018. The carbonyl bridge of THJ-2201 classifies it as a ketone. THJ-2201 is an analog of AM-2201 in which the core indole structure is substituted with an indazole base.

Pharmacology of THJ-2201

Although this substance has not been formally studied, from analysis of the structure, it is presumed that THJ-2201 has a similar binding profile to that of AM-2201 and matches many of the in vivo properties of Δ9-THC. As with AM-2201, this compound is believed to act as a potent full agonist to the central CB1 and peripheral CB2 receptors with Ki values of 1.0 and 2.6nM respectively. However, the role of these interactions and how they result in the cannabinoid high experience continues to remain elusive.

Subjective effects of THJ-2201

Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), an open research literature based on anecdotal user reports and the personal analyses of PsychonautWiki contributors. As a result, they should be viewed with a healthy degree of skepticism.

Spontaneous tactile sensations – The “body high” of THJ-2201 can be described as a warm, soft, pleasurable, all-encompassing tingling sensation that spreads over the body after initial ingestion. It maintains a consistent presence that quickly rises with the onset and hits its limit once the peak has been reached before immediately dissipating.
Sedation – Generally, the effects on the user’s energy levels are primarily sedating. This encourages one to relax, and (at higher doses) fall asleep. This can, however, be suppressed by simply forcing oneself to engage in physical activities.
Motor control loss – This substance causes a partial to moderate suppression of motor control which intensifies proportional to dose but rarely results in a complete inability to walk and perform basic movements.
Appetite enhancement – As with many other cannabinoids, THJ-2201 causes an increase in appetite, known colloquially as “the munchies” in popular American and United Kingdom culture. Clinical studies and survey data have found that cannabis increases food enjoyment and interest in food. This is thought to be due to the way in which endocannabinoids in the hypothalamus activate cannabinoid receptors that are responsible for maintaining food intake.
Vasodilation – Cannabinoids appear to decrease blood pressure by dilating the blood vessels, increasing blood flow throughout the body. The arteries in the eyeball expand from the decreased blood pressure, and the heart rate increases to compensate for the reduction in pressure.
Pain relief – Cannabinoids have been clinically demonstrated to provide pain relief via agonism of cannabinoid receptors CB1 and CB2, which extends to synthetic cannabinoid receptor agonists.
Perception of bodily lightness
Changes in gravity – THJ-2201 can cause vertigo with which the environment appears to be spinning or oscillating. At moderate to high doses, it can spontaneously induce the sensation of falling, which can be overwhelming and uncomfortable.
Nausea – THJ-2201 can induce feelings of nausea at strong to heavy doses, which can potentially lead to vomiting.
Abnormal heartbeat – This compound, like all cannabinoids, has commonly been reported to induce tachycardia in some individuals.
Dehydration- This is known colloquially as “cotton mouth” in popular American and United Kingdom culture